Quarterly Report-- July 1- September 30, 1953.

Read from the scan by GLM-OCR; expect the odd misread word.

Six patients, all negro male former addicts, volunteered for the experiment. In July, control observations were obtained. These included physical, psychological, psychiatric examinations, clinical observations three times daily, electrocardiograms, electroencephalograms, blood chemistry, and liver function tests. Following the control period, an attempt was made to determine the threshold dose (dose which would just induce mild subjective effects) for each patient. In this preliminary experiment, the drug was given daily. Initially, doses of 20 to 40 micrograms were administered and the dose was increased each day. Very few effects were observed until the dose had been increased to 100 micrograms. At this point, mild subjective effects were observed which, however, were not present when additional doses were given on subsequent days. Administration of 100 to 120 micrograms to patients who had not been receiving the drug daily induced powerful subjective effects. It was, therefore, felt that patients might have developed tolerance during the preliminary period. Daily administration of LSD-25 was therefore discontinued without the patient's knowledge, and, after six days, begun again. Immediately, very striking reactions were observed. For this reason it was necessary to obtain data on the effect of single isolated doses which were spaced at least three days apart.

Declassified by 187475

date 4 FEB 1977