Documents / FOIA release
This declassified quarterly report covers July 1 to September 30, 1953. It comes from the NIMH Addiction Research Center at the PHS Hospital in Lexington, Kentucky, and was signed by Director of Research Harris Isbell. It describes clinical, biochemical, neurophysiological and psychological studies of addiction, including trials of codeine substitutes, morphine and Nalline mixtures, meperidine addiction, and chronic LSD-25 intoxication, which produced rapid tolerance. It also lists the unit's publications, lectures and film showings. It does not discuss UFOs.
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Under these conditions a very consistent pattern of drug effect emerged. The degree and duration of the reactions were related to the dose. The amount of drug necessary to elicit the effect varied widely in different patients, the range extending from 90 to 300 micrograms. The objective effects of LSD-25 include elevation of systolic and diastolic blood pressure, dilatation of pupils (measured in controlled light), increased tendon reflexes, and decreased abdominal skin reflexes. Gooseflesh, fine intention tremor of the fingers, ankle clonus, and tremor of large muscle groups were less consistently observed. The mental effects of LSD-25 were very striking and varied from person to person. No obvious correlation with personality patterns was apparent. The mental effects consistently included anxiety, a feeling of unreality, and various haptic sensations (formication, feelings of electric shocks on the skin, tingling sensations, choking). Taste and smell appeared to be unaffected; noises were reported to be loud and difficult to distinguish; changes in the patient's body image, and in the body image of other persons were frequently reported; the patient's hands and feet appeared to grow, or decrease in size. Marked changes in visual perception were reported. These included blurring of vision, abnormal coloration of familiar objects (hands turning purple, green, etc.), doubts of paint on the wall, flickering A-58 Declassified by 187475 date 4 FEB 1977
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FOIA release, from the cia-readingroom collection. The PDF is mirrored here; the original link is above. The text was read from the page images by GLM-OCR; expect the odd misread word. 24 pages are in the text index: search them above, or from the library's search.