Documents / FOIA release
This declassified quarterly report covers July 1 to September 30, 1953. It comes from the NIMH Addiction Research Center at the PHS Hospital in Lexington, Kentucky, and was signed by Director of Research Harris Isbell. It describes clinical, biochemical, neurophysiological and psychological studies of addiction, including trials of codeine substitutes, morphine and Nalline mixtures, meperidine addiction, and chronic LSD-25 intoxication, which produced rapid tolerance. It also lists the unit's publications, lectures and film showings. It does not discuss UFOs.
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change in the EEC Synchronization of the electroencephalogram by photic stimulation appears to be enhanced after LSD-25 but the statistical significance of the changes observed remains to be evaluated. However, photic stimulation definitely enhanced perception of optical pseudo-hallucinations. ## 2. Experimental Psychology a. Effects of Morphine on Conditioned Inhibition in Rats (pain anxiety). The purpose of this experiment was to attempt to develop an analgesic testing method in rats, based on the same principle as that demonstrated in man—the reduction of anticipatory anxiety associated with pain. The method used was as follows: Adult rats were fed 70 per cent of the amount of food required to maintain their body weight. Rats were then placed in a modified Skinner box and trained to press a bar which released small pellets of food. Motivation under these conditions was, of course, hunger. After the rats had been trained and had attained a constant rate of bar pressing, rats were conditioned by sounding an electric buzzer terminated by an electric shock. After conditioning occurred, the rate of bar pressing became far less during the period of the buzz, but after the electric shock the rat would proceed to press the bar and obtain food pellets at his normal rate. Once stable conditioning had been established, morphine was Declassified by 187475 date 4 FEB 1977 A-49
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FOIA release, from the cia-readingroom collection. The PDF is mirrored here; the original link is above. The text was read from the page images by GLM-OCR; expect the odd misread word. 24 pages are in the text index: search them above, or from the library's search.