Documents / FOIA release
This declassified quarterly report covers July 1 to September 30, 1953. It comes from the NIMH Addiction Research Center at the PHS Hospital in Lexington, Kentucky, and was signed by Director of Research Harris Isbell. It describes clinical, biochemical, neurophysiological and psychological studies of addiction, including trials of codeine substitutes, morphine and Nalline mixtures, meperidine addiction, and chronic LSD-25 intoxication, which produced rapid tolerance. It also lists the unit's publications, lectures and film showings. It does not discuss UFOs.
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d. Addiction to meperidine in Chronic Spinal Dogs. In 2 nontolerant spinal dogs single doses of 10 mg./kg. of meperidine produced effects on the kindlimb reflexes which were similar to those produced by 0.75 mg./kg. of morphine. After a week on 10 mg. of meperidine every six hours, tolerance to the depressant effects was evident. At this time 15 mg./kg. of Nalline did not precipitate running movements. On the contrary, the flexor reflex was depressed and the dog appeared to be sedated after Nalline. When the number of doses of meperidine increased from four to eight daily, peculiar changes were observed in the paralyzed kindlimbs. These changes included marked hyperactivity of the ipsilateral flexor and crossed extensor reflexes, irregular spontaneous tremors, and twiches and massive extensor reflexes elicited by tapping any bony-proof protuberance below the level of cord section. After sixteen days of addiction, abrupt withdrawal was carried out for 24 hours. The changes observed persisted with increased intensity for 6 to 10 hours, then subsided moderately before the dogs were replaced on meperidine. At the moment, we are unsure whether the changes seen in the dogs addicted to meperidine represent toxic effects or obstinence symptoms. c. Effects of Diethylamide of Lysergic Acid (LSD-25) on the Human Electroencephalogram. In 6 subjects, single doses of LSD-25 varying from 90 to 150 micrograms produced little Declassified by 187475 date FEB 1977 A-5C
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FOIA release, from the cia-readingroom collection. The PDF is mirrored here; the original link is above. The text was read from the page images by GLM-OCR; expect the odd misread word. 24 pages are in the text index: search them above, or from the library's search.