Documents / FOIA release
This declassified quarterly report covers July 1 to September 30, 1953. It comes from the NIMH Addiction Research Center at the PHS Hospital in Lexington, Kentucky, and was signed by Director of Research Harris Isbell. It describes clinical, biochemical, neurophysiological and psychological studies of addiction, including trials of codeine substitutes, morphine and Nalline mixtures, meperidine addiction, and chronic LSD-25 intoxication, which produced rapid tolerance. It also lists the unit's publications, lectures and film showings. It does not discuss UFOs.
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c. Determining Addiction Liability in Dogs, Using Nalline. We are studying the possibility of developing a short test for addiction physical dependence liability in dogs, using Nalline. We have carried out preliminary experiments using two methods. The first method involves the injection of large amounts of the drug under study once daily for three to five days after which 15 mg./kg. of Nalline are administered. After injection of 50 mg./kg. of morphine for three to five days, Nalline caused definite changes in the behavior of dogs. After administration of Nalline the dogs became restless, sometimes vomited, developed tremors, and consistently would dig a hole at the foundation of the building and lie in it. These changes were not observed after either morphine or Nalline separately. Erratic results were seen after injection of single doses of methadone for three to five days. In the other method, drugs were given several times daily. When 5 mg./kg. of morphine was administered four times daily, Nalline precipitated digging and other changes after three to seven days of addiction. Intensity of the changes has been steadily increasing as morphine addiction proceeded. When 2 to 5 mg./kg. of methadone were administered four times daily, Nalline precipitated the digging and other changes after three to seven days of addiction. Such changes have not been observed in dogs that are being experimentally addicted to 10 mg./kg. of meperidine every three hours for 30 days. Declassified by 187475 date 4 FEB 1977 4-51
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FOIA release, from the cia-readingroom collection. The PDF is mirrored here; the original link is above. The text was read from the page images by GLM-OCR; expect the odd misread word. 24 pages are in the text index: search them above, or from the library's search.