Quarterly Report-- July 1- September 30, 1953.

Read from the scan by GLM-OCR; expect the odd misread word.

at the various dose levels, the experiments so far indicate that a large dose of Nalline antagonizes the depressant effects of morphine more than does a small dose. Conversely, a large dose of morphine antagonizes the effects of a fixed dose of Nalline more than does a small dose.

b. Addiction of Chronic Spinal Dogs to morphine-Nalline Mixtures. Two chronic spinal dogs were given 3.75 mg./kg of morphine and 1.25 mg./kg. of Nalline mixture of 3-to-11. After three weeks addiction to this mixture, there was no evidence of tolerance to the depressant effects of the mixture on the flexor reflex. This is a striking observation since, with morphine alone, marked tolerance would have been expected. In all dogs hyperreflexia and spontaneous running movements began to appear between the 9th and 19th days, immediately after each dose of the mixture. Above the level of section, mydriasis, tremor, rhinorrhea, salivation, etc., appeared sooner than did hyperreflexia or running movements in the hindlimbs. Findings in the dogs confirm these harms observed in man. They indicate that chronic use of morphine-Nalline mixtures would be associated with the development of unpleasant side effects (precipitation of mild abstinence by each injection of the mixture).

Declassified by 187475 date 4 FEE 1977

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