Documents / FOIA release
This declassified quarterly report covers July 1 to September 30, 1953. It comes from the NIMH Addiction Research Center at the PHS Hospital in Lexington, Kentucky, and was signed by Director of Research Harris Isbell. It describes clinical, biochemical, neurophysiological and psychological studies of addiction, including trials of codeine substitutes, morphine and Nalline mixtures, meperidine addiction, and chronic LSD-25 intoxication, which produced rapid tolerance. It also lists the unit's publications, lectures and film showings. It does not discuss UFOs.
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included not only a decline in the mental effects but also decreases in the effects on blood pressure, pupillary size and deep tendon reflexes. No abstinence occurred on withdrawal of LSD-25 after 14 days administration. Development of tolerance to LSD-25 occurs more rapidly and appears to be more complete than with any drug we have ever studied. The rapidity of the return of the effects remains to be determined. ## 2. Biochemical Studies ## a. Clinical Endocrinology of Addiction. The phase of this particular project described in the last quarterly report was completed during this quarter. In general, the excretion of 17-ketosteroids following 8-hour infusions of international units of ACTH during maintained addiction was less in terms of milligrams than prior to addiction. However the increase in terms of percentage of the usual daily excretion was greater during maintained addiction. In addition, 17-ketosteroids increased after infusions of only 5 and 2.5 international units of the preparation of ACTH used in these experiments. With the exception of one test on one man, the increase of 17-ketosteroid excretion after ACTH fall within the normal range. Increase in excretion of uric acid after infusions of ACTH appeared to be as great during maintained addiction as prior to addiction. The decline in eosinophil Declassified by 187475 date 4 FEB 1977
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FOIA release, from the cia-readingroom collection. The PDF is mirrored here; the original link is above. The text was read from the page images by GLM-OCR; expect the odd misread word. 24 pages are in the text index: search them above, or from the library's search.