Documents / FOIA release
This declassified quarterly report covers July 1 to September 30, 1953. It comes from the NIMH Addiction Research Center at the PHS Hospital in Lexington, Kentucky, and was signed by Director of Research Harris Isbell. It describes clinical, biochemical, neurophysiological and psychological studies of addiction, including trials of codeine substitutes, morphine and Nalline mixtures, meperidine addiction, and chronic LSD-25 intoxication, which produced rapid tolerance. It also lists the unit's publications, lectures and film showings. It does not discuss UFOs.
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count during timed ACTH infusions was somewhat slower during maintained addiction, but always fell to zero for nearly so in eight hours. Increase in excretion of 17-ketosteroids after the injection of 1000 international units of chorionic gonadotropin for five consecutive days was as great in terms of milligrams and in terms of percentage change from the usual excretion during addiction as during the control period. The data definitely show that the testes and the adrenal glands are capable of responding to the specific pituitary hormones during addiction to morphine. Nevertheless, excretion of 17-ketosteroids is markedly reduced during addiction and enhanced during withdrawal. Dr. Dorfmann of the Worcester Foundation for Experimental Biology, kindly analyzed a few samples of urine for us on patients who were addicted to morphine, and during acute withdrawal of morphine. The excretion of corticoids is much lower during maintained addiction. The most reasonable hypothesis explaining the facts known to date is a block at the pituitary level during morphine addiction. Future work will include determination of total adrenal- corticoid excretion (provided a suitable method can be developed); a fractionation of urinary corticoids by Dr. Dorfmann; and chorionic gonadotropin determinations to be done by the National Cancer Institute, provided certain technical difficulties Declassified by 187475 date FEB 1977
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FOIA release, from the cia-readingroom collection. The PDF is mirrored here; the original link is above. The text was read from the page images by GLM-OCR; expect the odd misread word. 24 pages are in the text index: search them above, or from the library's search.