Documents / FOIA release
This declassified quarterly report covers July 1 to September 30, 1953. It comes from the NIMH Addiction Research Center at the PHS Hospital in Lexington, Kentucky, and was signed by Director of Research Harris Isbell. It describes clinical, biochemical, neurophysiological and psychological studies of addiction, including trials of codeine substitutes, morphine and Nalline mixtures, meperidine addiction, and chronic LSD-25 intoxication, which produced rapid tolerance. It also lists the unit's publications, lectures and film showings. It does not discuss UFOs.
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with the development of intense cushorta. One patient was directly readdicted to MK-57 for a period of 17 days. The dose was increased from 2 mg. every three hours to 6 mg. every three hours. Even after this very short period of addiction, definite abstinence appeared on abrupt withdrawal. Abstinence was evident in four hours, severe by eight, and had subsided after forty-eight hours. The results confirm our impression that this drug has high addiction liability. (3) d1-1-methyl-4-phenyl-4-carbethoxy azacycloheptane No. 58351. Only preliminary work with this compound, which is in the meseridine series, has been completed. Single doses varying between 25 to 120 micrograms have been administered to 22 nontolerant former addicts. Evidence of morphine-like euphoria was observed in only 2 of these patients. No untoward toxic reactions have been encountered and the dose is still being elevated. (41) 4-4-d1phenyl-6-dimethylamino-hexanone-3 118. 105231. This compound, a member of the methadone series, is being examined at the request of the Drug Addiction Committee, since it is being marketed in Germany. The manufacturer has indicated that a combination of this drug plus Suprifen (p-hydroxy ephedrine) does not possess addiction liability. As yet only preliminary data are available. Single doses have been administered to 7 nontoxant morphine addicts. Evidence of mild 4-63 Declassified by ___187475___ date ___
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FOIA release, from the cia-readingroom collection. The PDF is mirrored here; the original link is above. The text was read from the page images by GLM-OCR; expect the odd misread word. 24 pages are in the text index: search them above, or from the library's search.