Documents / FOIA release
This declassified quarterly report covers July 1 to September 30, 1953. It comes from the NIMH Addiction Research Center at the PHS Hospital in Lexington, Kentucky, and was signed by Director of Research Harris Isbell. It describes clinical, biochemical, neurophysiological and psychological studies of addiction, including trials of codeine substitutes, morphine and Nalline mixtures, meperidine addiction, and chronic LSD-25 intoxication, which produced rapid tolerance. It also lists the unit's publications, lectures and film showings. It does not discuss UFOs.
Read from the scan by GLM-OCR; expect the odd misread word.
2. 5 to 60 mg. were administered to 17 nontolerant addicts. Definite evidence of morphine-like euphoria began to appear at the 30-mg. level. Euphoria was distinct and pronounced at the 60-mg. level. Euphoria was also observed when 60 to 75 mg. were administered orally. No untoward toxic reactions were observed. Sixty to 75 mg. of the levo isomer every four hours caused marked suppression of abstinence when substituted for morphine in 2 strongly addicted patients. No evidence of morphine-like euphoria was seen with the dextro compound, and no suppression of abstinence was observed during a short substitution for morphine. Although the number of patients tested is too small to draw definite conclusions, the results indicate that the levo isomer will possess addiction liability which will exceed that of codeine.
(2) $ \mathrm{O - M e l t h y l}=\Delta- \mathrm{O - d e s o x y m o r p h i n e} $ (MK-57).
It has previously been shown that this drug produced intense euphoria in former morphine addicts and was very effective in suppressing abstinence from morphine. The human pharmacology of the drug has now been studied in greater detail. In 10 patients it induced marked quollary constriction and marked respiratory depression. The peak of these effects was observed 15 minutes after administration of the drug and was associated
Declassified by ___187475___
date ___
A-64
FEB 1977 Not linked to a story yet.
FOIA release, from the cia-readingroom collection. The PDF is mirrored here; the original link is above. The text was read from the page images by GLM-OCR; expect the odd misread word. 24 pages are in the text index: search them above, or from the library's search.