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This Defense Intelligence Reference Document, dated 31 March 2010 and numbered DIA-08-1003-020, was prepared by the Defense Intelligence Agency's Defense Warning Office under its Advanced Aerospace Weapon System Applications Program. It surveys biosensors and biomedical microelectromechanical systems, covering brain-implanted micromachine neuroelectrodes, drug-delivery pumps, glucose sensors, neural interfaces, retinal prostheses, microfluidic lab chips, NASA cell-culture systems and microcantilever sensors. It concludes that the field is expanding rapidly, with nanomechanical systems expected to follow.
From the source: Release of 2026-09-18 Incident: 3/31/10, Las Vegas, Nevada. Released with redactions. This document is a Defense Intelligence Reference Document (DIRD), a technical reference format used by the Defense Intelligence Agency (DIA) to capture baseline knowledge on a specific topic for later analytic use. DIRDs are best understood as reference and synthesis products rather than as original research. It is one of 38 DIRDs produced under the Advanced Aerospace Weapon System Applications Program (AAWSAP) between 2009 and 2011. Because AAWSAP’s scope permitted a broad range of supporting topics, not every DIRD in the series directly concerns aerospace systems or future threat assessment. The following summary reflects the DIRD’s scope and framing at the time of writing and should not be read as implying current validation of the concepts discussed. This DIRD surveys biosensors and BioMEMS, a broad class of miniature biomedical devices that combine microscale engineering with sensing, fluid handling, stimulation, or drug-delivery functions. The report reviews major application areas including implantable blood-chemistry sensors, neural interfaces, neurostimulation, drug-delivery pumps, microfluidic systems, and emerging nanoscale extensions of the field, while emphasizing that miniaturization can improve sensitivity and enable functions that are difficult or impossible at larger scales. However, it also makes clear that practical development is constrained by biocompatibility, long-term stability, sensor drift, device degradation inside the body, and the high regulatory burden associated with implantable medical systems. The document presents BioMEMS as a rapidly growing and productive field whose future advances are likely to come through continued improvements in fabrication, materials, and reliability.
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have a significant problem in controlling their blood sugar and sometimes insulin doses
are not adjusted finely enough or frequently enough to maintain the blood glucose at
healthy levels. This form of diabetes is responsible for fainting (ketoacidosis) and other
serious symptoms such as poor blood circulation to the limbs. Poor circulation can
result in diabetic ulcers and may sometimes necessitate amputation of the limb.
Insulin pumps are often worn by brittle diabetics because a slow infusion of insulin
works better in stabilizing blood glucose levels rather than periodic injections. A belt
worn insulin-delivery system looks something like an old-style audio player. These
systems are typically controlled by a small screw-type pump powered by batteries. The
reservoir carries several milliliters of insulin for dispensing over an extended period of
time. The injection needle is connected (underneath the clothes) to a catheter and then
to the pump. The systems are reasonably effective but are cumbersome and require the
needle to continuously reside subcutaneously in the abdomen.
A MEMS implanted insulin pump is a less cumbersome and perhaps more convenient
means of slowly infusing insulin at a programmed rate. The implanted device is refilled
periodically by introducing a needle through the skin and tissue to a septum in the
device.
The MEMS insulin pump shown in Figure 6 is surgically placed under the skin. It has a
rubber septum on the top for filling with insulin. This implementation has a piezoelectric
element that moves in response to electrical charge. When actuated by a timer the
element oscillates, creating a pressure inside the device that dispenses insulin. The
device is programmable for dispensing at various rates.
Although the implantable MEMS pump was developed for diabetes, the pump has
application to the slow measured delivery of many other drugs including 5-fluoruracil
used for cancer therapy and theophyllne for treatment of asthma.
What is a Biosensor?
A primary application of BioMEMS is in the creation of sensors for blood chemistry and
other biophysical parameters of the human body.
We can define a Biosensor as:
• A sensor whose application is primarily in the measurement of quantities within a
biological system, such as chemical, electrical, and physical parameters.
• A sensor incorporating a biological component (enzymes, living cells, antibodies)
typically used to measure chemical concentration. This definition does not require
that the sensor be deployed within a biological system.
The two definitions wh ich are somewhat different have their origin with different
influential investigators who wrote textbooks in the early days of this field. The latter
definition is prevalent in Europe.
A biosensor is normally constructed by immobilizing a biologically active material (such
as an enzyme) onto an electrical sensor that measures a fundamental physical quantity
like electrical current, voltage, mechanical strain, temperature, or frequency. The
specific sensor material is chosen because it reacts to a desired measurand (such as
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Official release, from the pursue collection. The PDF is mirrored here; the original link is above. 45 pages are in the text index: search them above, or from the library's search.