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This Defense Intelligence Reference Document from the Defense Intelligence Agency, dated 10 December 2010, is one of a series of advanced technology reports produced in FY 2010 under the Advanced Aerospace Weapon System Applications (AAWSA) Program. It reviews quantum computing technologies and DNA-based molecular computing for onboard supercomputing on future spacecraft. It forecasts ion-trap quantum computers within 10 years, simple DNA tile computing within 20 years, and self-repairing DNA computers on a 40-year horizon.
“The Advance”7 pages
UNCLASSIFIED//F8R: 8FFHiillk 1155 011! X Deoxyribozyme-based Boolean Automata The deoxyribozyme logic gates were applied to the construction of the first DNA-based Boolean automata capable of autonomously responding to human inputs: "MAYAs" are automata playing a game of tic-tac-toe against a human player. In tic-tac-toe there are a maximum of 4 moves by the human player when MAYA has the first move. The initial MAYA automaton played a simplified game, always claiming the center first, and the first human move is symmetry-restricted to one corner or one side move. These simplifications led to a representation of the game as a series of Boolean formulae that compute the automaton's output in each well, based on the human inputs present in all wells. These formulae were mapped to 23 deoxyribozyme-based logic gates by arranging gates in the individual wells around a common substrate. These "hard-wired" automata give the human no chance to win (Figure 22, Figure 23). (120, 122) One, two and three input deoxyribozyme-based logic gates are allosterically modulated by 32 human-operated input oligonucleotides: 97 logic gates distributed across 9 wells which calculate automaton moves, and 32 gates (boxed) display human moves by implementation of a two-color fluorogenic output system. Even though this mechanism is simplistic in nature, it has performed flawless Boolean calculations. a ' f 'c"''''l'''"rn1,.c---: T - '. , , ',E6 H d r .-.·r •_,T -,--~ '---' " ,, . 111 ,,Ji) ' e c;p ff.1 C NOTii; , o., T :,;-' --.__co" 0 (3) } .-o•, .'0' Figure 22. Basic gate structures, derived from allosterically regulated deoxyribozyme E6, for playing tic-tac- toe against a human opponent. The truth tables constructed are sufficient to ensure the human player cannot win the game. (120) 39 UNCLASSIFIED//FOR OFSJCJ0I IPSF ONI X
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Report, from the dia collection. The PDF is mirrored here; the original link is above. 54 pages are in the text index: search them above, or from the library's search.