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This Defense Intelligence Reference Document from the Defense Intelligence Agency, dated 10 December 2010, is one of a series of advanced technology reports produced in FY 2010 under the Advanced Aerospace Weapon System Applications (AAWSA) Program. It reviews quantum computing technologies and DNA-based molecular computing for onboard supercomputing on future spacecraft. It forecasts ion-trap quantum computers within 10 years, simple DNA tile computing within 20 years, and self-repairing DNA computers on a 40-year horizon.
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UNCLASSIFIED//FOR OFFICIO I 1!55 All! X constant concentration around the crystal can easily be realized by a constant flow. This ground-breaking work in DNA synthesis technology has opened the door for several applications in genetic engineering and lab on a chip technology (107)(108)(109). This kind of controlled self-assembly will drastically improve the size and yield of errorless nano structure. It is also possible to produce desired nano structures on a patterned template in the reaction chamber for various applications. GIJSS [,lote /01frJme Figure 16. Micro-fluidic device for DNA tile self-assembly. DNA Origami The idea of holding helical domains in a parallel arrangement via the juxtaposition of antiparallel crossovers has become a general principle in DNA nanotechnology, used in at least a dozen constructions. For example, it has been extended to molecules with three parallel helixes (110) and it has been used to attach triangles rigidly to a nanomechanical device. (111) However, these techniques do not create a generalized multi-crossover molecule with parallel helices due to the inability to have the ratio of the component short strands exactly equal. Single-stranded origami such as William Shih's octahedron (113) cannot, by definition, suffer from this problem. Scaffolded origami sidesteps the problem of equalizing strand ratios by allowing an excess of helpers to be used. As long as each scaffold strand gets one of each helper, all scaffolds may fold correctly (some might get trapped in misfolding). Because origami are easily differentiable from the helpers, separating them is not difficult (e.g. large origami stick much more strongly to mica surfaces than do tiny helpers and so excess helpers can be washed away). Single-stranded origami and scaffolded origami thus seem the best candidates for the creation of large complex structures. As Shih has observed, the geometry used for the octahedron should generalize and allow the creation of arbitrary polygonal networks. Generalization of the parallel helical geometry introduced by double- crossover molecules is simple using scaffolded DNA origami; Ruthemond has recently demonstrated the technique for the creation of six arbitrary shapes and six arbitrary patterns (including the one shown here); the design method and experiments showing its generality are described in (114). To get a feeling for the method, look at Figure 18. Shapes are approximated by laying down a series of parallel helical domains inside of the shape (Figure 18a). Helices are cut to fit the shape, in a series of sequential pairs from top to bottom, so 32 UNCLASSIFIED;;, Oil orrU!IIIL i.&iii 1Uib¥
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Report, from the dia collection. The PDF is mirrored here; the original link is above. 54 pages are in the text index: search them above, or from the library's search.