Documents / Report
This Defense Intelligence Agency reference document, dated 31 March 2010 (DIA-08-1003-020), was one of a series of advanced technology reports produced in FY 2009 under the Advanced Aerospace Weapon System Applications (AAWSA) program. It surveys biosensors and BioMEMS, covering brain-implanted neuroelectrodes, drug-delivery pumps, implantable glucose sensors, brain-machine interfaces, retinal prostheses, microfluidic lab chips, NASA cell culture systems, and microcantilever sensors. It concludes that the field is expanding rapidly toward nanomechanical systems.
UNCLASSIFIED//F'ilA WFFUil.-ik lallilii W•lklf needed to culture living cells, in volumes of less than a milliliter. The device contains thermopneumatic micropumps, microvalves, culture media reservoirs, cell culture chamber, and optical readout systems to detect fluorescent markers that the cells express when subjected to certain types of stress. Sensors for glucose, oxygen, and pH monitor the culture medium and work with a servo system to keep culture conditions within a narrow range. One of the designed cell culture systems can be seen in Figure 32. The system is made from micromachined acrylic, and has fluidic pathways defined as channels in the plastic. The entire system is first laid out using a CAD (computer aided design) system and then machined to fine tolerances and chemically polished. -P,,~, ,, ,\'~;l~/ Figure 32. Design of an Automated Cell Culture System for NASA Space Applications Incorporating Microfluidics and Integrated Optical Components (Towe et. al.) Figure 33 shows a more compact version of the device which contains two integrated optical cells designed to monitor the expression of green fluorescent protein (GFP) and 35 UNCLASSIFIED/ ,<EiOAt OEiEiIGIPk IP&'i Ollk¥
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Report, from the dia collection. The PDF is mirrored here; the original link is above. 45 pages are in the text index: search them above, or from the library's search.