Documents / Report
This Defense Intelligence Agency reference document, dated 31 March 2010 (DIA-08-1003-020), was one of a series of advanced technology reports produced in FY 2009 under the Advanced Aerospace Weapon System Applications (AAWSA) program. It surveys biosensors and BioMEMS, covering brain-implanted neuroelectrodes, drug-delivery pumps, implantable glucose sensors, brain-machine interfaces, retinal prostheses, microfluidic lab chips, NASA cell culture systems, and microcantilever sensors. It concludes that the field is expanding rapidly toward nanomechanical systems.
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UNCLASSIFIED/ ,sr&R: 8FFI8Itlrt 1!181!! 8HL'f The !\ anoCh 1p1_ R: 4::)0 cartridge c:onstru::ts the user defined panel of genetic r1arkers on one chip ~....:... ~~., ;, ..:.',,,L.c.,.,~ ;. . -· ,,,.....::..... __ _.,,....:.,.•_,_..._ - -·---- ---··· -----· A.ff:,r,etr1x ~NN,· .af(,· retr1x.com Caliper fe:r,r·:i10::i1es: ·:.•:,-,._ :a·1perte~r-, :::ir Figure 31. Commercial Lab-Chip Devices That Allow Analysis for Biomarkers of Various Diseases Using on-Chip Electrophoresis in Microscale (collage from manufacturers listed) These MEMS devices incorporate micro-scale fluidic components, sensors, actuators, and customized surfaces created by chemical modification or coating with inorganic and organic materials; enabling tissue engineering and cell patterning studies along with the microfluidic control of the culture environment. NASA SPACE APPLICATIONS FOR MICROFLUIDIC SYSTEMS NASA has supported at Arizona State University, the development of new types of microfluidic systems directed towards growing cell cultures on a chip. The specific application is detecting the effects of space flight and microgravity on living things at the cellular scale. Space presents a number of stresses on the cells of the astronaut's body from electromagnetic fields, microgravity, and space cabin environments, which in combination have effects that are likely different than any single stress. Beyond affecting the astronaut directly, space flight can change any organism, and actually makes some bacteria more dangerous. Cells can be grown to represent the cells of the astronaut's body. Changes in DNA expression or molecular stress markers in cultured cells can be used to infer effects of space. Culturing mammalian cells in the laboratory generally requires constant attendance and adjustment, but astronauts have little time for routine culture procedures. Thus NASA supported the design of an automated microfluidic system to perform all the steps 34 UNCLASSIFIED/ ,'P8"1 8PPll!l"'I! l!l!il! 8111!¥
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Report, from the dia collection. The PDF is mirrored here; the original link is above. 45 pages are in the text index: search them above, or from the library's search.