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(Estimated Pub Date) Volume 2 Re Intravenous Toxicity to Mice Reaction Sign; Physical and Neurological Examination of Cats; and Other Statistical Reports. (Projects Unknown; Undated)

Central Intelligence Agency · 1966-01-01 · 438 pages · text by OCR

This undated Central Intelligence Agency release, catalogued with an estimated date of 1966, is Volume 2 of a set of pharmacological test data on compounds identified only by number, from unknown projects. It holds tables on intravenous toxicity in mice, giving LD50 and MED50 values and reaction signs. It also has tables on the dominance behavior of squirrel monkeys and on blood pressure, heart rate and respiration in chloralosed cats. The text contains no conclusions and does not mention aerial phenomena.

LD50 56.00 =18.00=150.00=

MED50 3.02=3=1.00=3=1.00=3=

RATIO LD50/MED50 175,000

STATE SOLIC

DOSE
MG/KG	DILUT
ML/KG	REACT
FRACT	INTRAVENOUS TOXICITY TO MICE
REACTION SIGN	MIN.
APPR	DEG-
REE	MEN. TO
RECOVER
100.0	10.0	2/2	DEATH	74	0
32.0	3.2	2/2	DEC LOCOMOTOR ACTIVITY	124	30	$\cdot$	240
32.0	3.2	2/2	INC SENSITIVITY TO TOUCH	131	60	$\cdot$	240
32.0	3.2	2/2	PINNAL REFLEX DEPR	331	30	$\cdot$	60
32.0	3.2	2/2	HEAD TWITCH	531	60	$\cdot$	280
32.0	3.2	2/2	SOCIAL INTERACTION ALTERED	132	0 240
32.0	3.2	2/2	DEC REARING FREQUENCY	632	30 240
32.0	3.2	2/2	TREMORS=REST AND MOVEMENT	144	0	$\cdot$	120
32.0	3.2	2/2	INC RESPIRATORY DEPTH	161	0 8
32.0	3.2	1/2	DEC RESPIRATORY DEPTH	261	8 60
32.0	3.2	2/2	INC RESPIRATORY RATE	162	0	$\cdot$	8
32.0	3.2	1/2	DEC RESPIRATORY RATE	262	15 60
32.0	3.2	2/2	IRREGULAR RESPIRATORY RATE	362	15 60
32.0	3.2	2/2	RESTLESSNESS	79	30 190
10.0	10.0	2/2	INC LOCOMOTOR ACTIVITY	224	60	$\cdot$	120
10.0	10.0	2/2	DEC LOCOMOTOR ACTIVITY	124	120	$\cdot$	240
10.0	10.0	2/2	INC SENSITIVITY TO TOUCH	131	60	$\cdot$	240
10.0	10.0	2/2	SOCIAL INTERACTION ALTERED	132	0 240
10.0	10.0	2/2	TREMORS=REST AND MOVEMENT	144	0	$\cdot$	120

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FOIA release, from the cia-readingroom collection. The PDF is mirrored here; the original link is under it. The text was read from the page images by an OCR model; expect the odd misread word. 438 pages are in the text index: search them above, or from the library's search.